It is crucial to replicate the micromechanical milieu of native tissues to achieve efficacious tissue engineering and regenerative therapy. In this study, we introduced an innovative loading platform, EQUicycler, that utilizes a simple, yet effective, and well-controlled mechanism to apply physiologically relevant homogenous mechanical equiaxial strain on three-dimensional cell-embedded tissue ...

The mechanical properties of the Ti-6Al-7Nb alloy, used to manufacture high-strength prostheses, are highly dependent on its microstructure. This work presents the microstructural changes of this alloy under isothermal hot working. It is shown that microstructure is strongly affected by strain rate, temperature and strain. The possible precipitation of intermetallic phases is also evaluated. To...

The study reports the mechanical property and microstructure of cold rolled low carbon steel and its work-hardening behavior in the deformation process. The tensile test in room temperature of low carbon steel was implemented for the different cold rolling deformation, the stress-strain curve was draught according to the relationship between strength and deformation and fitted for the polynomia...

An available novel system for studying the cellular mechanobiology applies an equiaxial strain field to cells cultured on a PolyDiMethylSiloxane (PDMS) substrate membrane, which is stretched over the deformation of a cylindrical shell. In its application of in vitro cell culture, the in-plane strain of the substrate membrane provides mechanical stimulation to cells, and out-of-plane displacemen...

Two-dimensional electron back-scattered diffraction (2D-EBSD) mapping has been widely used for indicating the polycrystalline plasticity through intragranular misorientation parameters KAM and GROD, based on empirically linear relationship between their average values mesoscopic plastic strain, in both stretched cyclically deformed metals. However, whether measured 2D-EBSD observational plane o...

The release of surfactant from alveolar type II cells is essential to lower the surface tension in the lung and to facilitate inspiration. However, the factors controlling dispersal and diffusion of this hydrophobic material are still poorly understood. Here we report that release of surfactant from the fused vesicle, termed lamellar body (LB), resisted mechanical forces applied by optical twee...

Cyclic mechanical stretching, including uniaxial strain, has been manifested to regulate the cell morphology and functions directly. In recent years, many techniques have developed apply cyclic stretching cells in vitro. Pneumatically actuated is one of extensively used methods owing its advantages integration, miniaturization, long-term stretching. However, intrinsic difficulty fabrication adj...